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Studying Bipolar Disorder with Induced Pluripotent Stem MP3 - NAMI 2017

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Item Number: NAMI-17-035-M
Bipolar disorder (BP) is a severe mood disorder affecting 5.7 million adults each year. Genetic studies have identified several genetic variants that increase risk for BP, but exactly how these variants increase risk is unknown. One important gene identified in multiple genetic studies of BP is the calcium channel gene, CACNA1C. This project investigates the cellular and molecular impacts of calcium signaling in st em cells from people with BP. Preliminary data suggest that their neurons have different calcium signaling patterns. These studies will help us better understand the mechanisms of genetic risk for BP and may help identify targets for new treatment options. Aislinn Williams, Ph.D., Clinical Lecturer, Dept. of Psychiatry, University of Michigan, Ann Arbor, Mich
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